张伟 副理事长

1张 伟, 男,1957年10月生,药理学教授,药理药剂内科学研究生导师。1990年6月研究生毕业于安徽医科大学心血管药理专业,获医学硕士学位,无党派人士。现任南通大学医学院药理学系主任,南通大学医药研究所所长,南通大学药学(省重点一级学科培育点)学科带头人;南通大学省优势学科《基础医学》学科(群)学术带头人(PI)。南通伟康医药研究院院长(独立法人),南通市生物医药重点实验室常务副主任,中国药理学会理事,江苏省药理学会副理事长,江苏省药理教学委员会副主任委员,江苏省新药临床前研究专业委员会副秘书长,南通市药学会药剂药理专业委员会主任委员。

从事新药研究与开发三十多年,先后主持或与企业合作承担各类中西医药研发项目30多项,绝大多数成果转化为生产力,其中有知名品牌“盖天力”、“富硒康”、“安奇”等,有“九五”科技攻关项目抗高血压新药Moxonidine、抗炎新药Tenoxicam等,技术贸易(技术开发、技术服务、技术转让)达1000多万,近年来主持国家、省、市厅级研究课题9项,获市厅级科技进步二等奖3项(名第一), 作为通讯作者(或第一作者)在国内外核心与权威期刊发表专业学术论文40多篇,拥有国家授权发明专利5项。

通讯作者(或第一作者)代表作:

15.Stat3 pathway correlates with the roles of leptin in mouse liver fibrosis and sterol regulatory element binding protein-1c expression of rat hepatic stellate cells Int J Biochem Cell Biol.. 2013 Mar;45(3):736-44.

14.Two novel hydroperoxylated products of 20(S)-protopanaxadiol by Mucor racemosus and their cytotoxic activities against human prostate cancer cells Biotechnol Lett. 2013 Mar;35(3):439-43.

13.Proteomic analysis for anti-atherosclerotic effect of tetrahydroxystilbene glucoside in rats. Biomed Pharmacother. 2012 Nov 15.doi:pii: S0753-3322PMID: 23178522

12.Microbial transformation of 20(S)-protopanaxadiol by Absidia corymbifera. Cytotoxic activity of the metabolites against human prostate cancer cells.

Fitoterapia. 2013 Jan;84:6-10

11.The effect of 2, 3, 4′, 5-tetrahydroxystilbene-2-0-?-D glucoside on neointima formation in a rat artery balloon injury model and its possible mechanisms

Eur J Pharmacol. 2013 Jan ;698(1-3):370-8

10.MiR-17-3p Inhibits Angiogenesis by Downregulating Flk-1 in the Cell Growth Signal Pathway. J Vasc Res. 2012 Dec;50(2):157-166.

9.Electrical Field Stimulation Induces Cardiac Fibroblast Proliferation through Calcineurin-NFAT Pathway.

Can J Physiol Pharmacol. 2012 Dec;90(12):1611-22.

8.SKF83959, an Agonist of the Phosphatidylinositol-Linked D1-Like Receptors, Promotes ERK1/2Activation and Cell Migration in Cultured Rat Astrocytes.

PLoS One. 2012 Nov;7(11):e49954.

7.2,3,4’,5-Tetrahydroxystilbene-2-0-beta-D-glucoside inhibits proliferation of

Vascular? smooth muscle cells:involvement of NO/cGMP/PKG pathway.

Phytotherapy Research. 2012 Jul;26(7):1068-74

6.2,3,4′,5-Tetrahydroxystilbene-2-O-beta-D-glucoside Inhibits angiotensin II-induced

cardiac fibroblast proliferation through suppression of reactive oxygen species-ERK1/2

pathway. Clin Exp Pharmacol Physiol. 2012 May;39(5):429-37.

5.2,3,4′,5-Tetrahydroxystilbene-2-0-beta-D-glucoside inhibits platelet-derived growth

factor-induced proliferation of vascular smooth muscle cells by regulating cell cycle.

Clin Exp Pharmacol Physiol. 2011May;38(5):307–313

4.Ca2+?calmodulin-dependent protein kinase IIδ orchestrates G-protein-coupled

receptor and electric ?0?3eld stimulation-induced cardiomyocyte hypertrophy

Clin Exp Pharmacol Physiol 2010 Aug;37(8):795–802

3.Inhibition of Calcium-Calmodulin-Dependent Kinase II Suppress Cardiac

Fibroblast Proliferation and Extracellular Matrix Secretion .

J Cardiovasc Pharmacol? 2010 Jan;55(1):96-105

2.Effects of 2,3,4’,5-Tetrahydroxystilbene-2-0-β-D-glucoside on vascular endothelial

dysfunction in atherogenic-diet rats Planta Medicinal 2009 Sep;75:1209-1214

1.2,3,4’,5-TETRAHYDROXYSTILBENE-2-O-β-D-GLUCOSIDE SUPPRESSES MATRIX METALLOPROTEINASE EXPRESSION AND INFLAMMATION IN ATHEROSCLEROTIC

RATS. Clin Exp Pharmacol Physiol 2008 Mar;35(3):310-6.

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